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PMID: 6303472 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effect of several nucleotides on the phosphorylating activities of the Rous-sarcoma-virus transforming protein pp60v-src and its cellular homologue, pp60c-src.

Bioscience reports ·Vol. 3 ·No. 2 ·1983-02-00 ·Pages 153-62

Barnekow A

Abstract

In the presence of ADP and GDP the tyrosine-phosphorylating activities of the viral as well as the cellular pp60src show a similar concentration-dependent inhibition in vitro. Addition of diadenosine 5',5"'-p1p4 tetraphosphate (Ap4A) to the kinase assay leads to an inhibition of the viral kinase activity, whereas the cellular kinase is not influenced.

MeSH Terms

Adenine Nucleotides/pharmacology Adenosine Diphosphate/pharmacology Animals Avian Sarcoma Viruses/enzymology Cell Transformation, Neoplastic Cell Transformation, Viral Chick Embryo Dinucleoside Phosphates Guanosine Diphosphate/pharmacology Mice Nucleotides/pharmacology Oncogene Protein pp60(v-src) Phosphorylation Protein Kinase Inhibitors Viral Proteins/antagonists & inhibitors

Chemicals

Adenine Nucleotides Dinucleoside Phosphates Nucleotides Protein Kinase Inhibitors Viral Proteins Guanosine Diphosphate diadenosine tetraphosphate Adenosine Diphosphate Oncogene Protein pp60(v-src)

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Barnekow A

Article Info

Journal

Bioscience reports

Abbr.

Biosci Rep

ISSN

0144-8463

DOI

10.1007/BF01121946

Published

1983-02-00

Pages

153-62

Language

English

Region

England

NLM ID

8102797

Subset

External Links

PubMed source DOI: 10.1007/BF01121946 View journal details

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Effect of several nucleotides on the phosphorylating activities of the Rous-sarcoma-virus transforming protein pp60v-src and its cellular homologue, pp60c-src.

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