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PMID: 6301005 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.

Science (New York, N.Y.) ·Vol. 220 ·No. 4594 ·1983-04-15 ·Pages 323-5

Honchar MP, Olney JW, Sherman WR

Abstract

Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain. The syndrome was preventable with atropine. The physostigmine doses and concentrations of blood lithium that caused the syndrome are similar to those considered appropriate for psychiatric chemotherapy.

MeSH Terms

Animals Atropine/pharmacology Brain Chemistry/drug effects Chlorides/adverse effects Drug Interactions Humans Inositol/analogs & derivatives,analysis Inositol Phosphates Lithium/adverse effects Lithium Chloride Male Parasympathomimetics/adverse effects Physostigmine/adverse effects Pilocarpine/adverse effects Rats Rats, Inbred Strains Seizures/chemically induced Substance-Related Disorders/etiology

Chemicals

Chlorides Inositol Phosphates Parasympathomimetics Pilocarpine inositol 1-phosphate Inositol Atropine Lithium Physostigmine Lithium Chloride

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Honchar M P

Olney J W

Sherman W R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6301005

Published

1983-04-15

Pages

323-5

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIMH NIH HHS · MH-14677 · United States

NIMH NIH HHS · MH-38894 · United States

NINDS NIH HHS · NS-05159 · United States

External Links

PubMed source DOI: 10.1126/science.6301005 View journal details

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Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.

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