The rat fibrinogen genes. Linkage of the A alpha and gamma chain genes.

We have utilized cDNA probes for the alpha, beta, and gamma chains of rat fibrinogen to isolate the corresponding genes from two rat genomic libraries constructed in bacteriophage Charon 4A. There is a single copy of each gene. Mapping of greater than 92 kilobase pairs of rat genomic DNA has shown that the gamma and alpha chain genes are directly linked in a 5'-3' direction in vivo.