1 alpha,25-Dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 1 ·1983-01-00 ·Pages 201-4

Honma Y, Hozumi M, Abe E, Konno K, Fukushima M, Hata S, Nishii Y, DeLuca HF, Suda T

Abstract

Syngeneic SL mice inoculated with murine myeloid leukemia cells (M1) all died of leukemia within 30 days. Treatment three times a week with 12.5-50 pmol per mouse of either 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], the active form of vitamin D3, or its synthetic analog, 1 alpha-hydroxyvitamin D3 [1 alpha(OH)D3], considerably prolonged the survival time of mice inoculated with M1 cells. 1 alpha(OH)D3 was more effective than 1 alpha,25(OH)2D3 in increasing the survival time of the mice. 1 alpha(OH)D3 also increased the survival time of nude mice inoculated with M1 cells. The 1 alpha(OH)[3H]D3 administered intraperitoneally to tumor-bearing mice was converted very rapidly to 1 alpha,25(OH)2-[3H]D3. The chronic administration of 25 pmol of 1 alpha(OH)D3 to tumor-bearing mice for 30 days caused no appreciable hypercalcemia. These results indicate clearly that 1 alpha,25(OH)2D3 is effective not only in inducing differentiation of M1 cells in vitro, as previously reported [Abe, E., Miyaura, C., Sakagami, H., Takeda, M., Konno, K., Yamazaki, T., Yoshiki, S. & Suda, T. (1981) Proc. Natl. Acad. Sci. USA 78, 4990-4994], but also in prolonging the survival time of mice inoculated with M1 cells.

MeSH Terms

Animals Calcitriol/therapeutic use Calcium/blood Cholecalciferol/therapeutic use Hydroxycholecalciferols/metabolism,therapeutic use Leukemia, Experimental/drug therapy Mice Neoplasm Transplantation Phosphorus/blood

Chemicals

Hydroxycholecalciferols Cholecalciferol Phosphorus Calcitriol Calcium

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Honma Y

Hozumi M

Abe E

Konno K

Fukushima M

Hata S

Nishii Y

DeLuca H F

Suda T

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.80.1.201

Published

1983-01-00

Pages

201-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC393339

Subset

External Links

PubMed source DOI: 10.1073/pnas.80.1.201 PMC Full Text View journal details

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1 alpha,25-Dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells.

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