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PMID: 6296837 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Isolated poliovirus capsid protein VP1 induces a neutralizing response in rats.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 23 ·1982-12-00 ·Pages 7518-21

Chow M, Baltimore D

Abstract

Antibodies were raised in rats against the poliovirus type 1 capsid proteins, VP1, VP2, and VP3. Antibodies directed against VP1 from type 1 poliovirus (Mahoney) neutralized type 1 but not type 2 poliovirus. Antibodies raised against VP2 and VP3 failed to neutralize type 1 virus. Thus, VP1 appears to be a neutralizing antigen for poliovirus and in its denatured form presents to the immune system its neutralizing determinants.

MeSH Terms
Animals Antibodies, Viral/immunology Antigens, Viral/immunology Capsid/immunology Poliovirus/immunology Rats Viral Plaque Assay Viral Proteins/immunology Viral Vaccines
Chemicals
Antibodies, Viral Antigens, Viral Viral Proteins Viral Vaccines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chow M
Baltimore D
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22 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.23.7518
Published
1982-12-00
Pages
7518-21
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC347371
Subset
IM
Grants
NIAID NIH HHS · AI08388 · United States
NCI NIH HHS · CA14051 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.23.7518 PMC Full Text View journal details
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