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PMID: 6286044 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Rapid appearance of intraventricularly administered neuropeptides in the peripheral circulation.

Brain research ·Vol. 241 ·No. 2 ·1982-06-10 ·Pages 335-40

Passaro E, Debas H, Oldendorf W, Yamada T

Abstract

125I-Labeled cholecystokinin octapeptide ([125I]CCK-OP) diffuses rapidly by a non-carrier-mediated mechanism into the peripheral blood following injection into the lateral ventricle of a rabbit. In contrast, no [125I]CCK-OP was observed in the CSF following intravenous injection. This unidirectional free transport mechanism from CSF to blood may apply to other neuropeptides as well.

MeSH Terms

Animals Appetite Depressants/administration & dosage Cholecystokinin/administration & dosage,blood,cerebrospinal fluid Injections, Intraventricular Iodine Radioisotopes Kinetics Peptide Fragments/administration & dosage,blood,cerebrospinal fluid Rabbits Sincalide

Chemicals

Appetite Depressants Iodine Radioisotopes Peptide Fragments Cholecystokinin Sincalide

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Passaro E

Debas H

Oldendorf W

Yamada T

Article Info

Journal

Brain research

Abbr.

Brain Res

ISSN

0006-8993

Published

1982-06-10

Pages

335-40

Language

English

Region

Netherlands

NLM ID

0045503

Subset

Grants

NIADDK NIH HHS · AM17328 · United States

NIADDK NIH HHS · AM26268 · United States

External Links

PubMed source View journal details

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Rapid appearance of intraventricularly administered neuropeptides in the peripheral circulation.

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