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PMID: 6283182 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Synthesis of coronavirus mRNAs: kinetics of inactivation of infectious bronchitis virus RNA synthesis by UV light.

Journal of virology ·Vol. 42 ·No. 2 ·1982-05-00 ·Pages 755-9

Stern DF, Sefton BM

Abstract

Infection of cells with the avian coronavirus infectious bronchitis virus results in the synthesis of five major subgenomic RNAs. These RNAs and the viral genome form a 3' coterminal nested set. We found that the rates of inactivation of synthesis of the RNAs by UV light were different and increased with the length of the transcript. These results show that each RNA is transcribed from a unique promoter and that extensive processing of the primary transcripts probably does not occur.

MeSH Terms

Coronaviridae/radiation effects Infectious bronchitis virus/genetics,radiation effects Kinetics Models, Genetic Operon RNA, Messenger/biosynthesis RNA, Viral/biosynthesis Transcription, Genetic/radiation effects Ultraviolet Rays

Chemicals

RNA, Messenger RNA, Viral

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Stern D F

Sefton B M

References (29)

29 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.42.2.755-759.1982

Published

1982-05-00

Pages

755-9

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC256903

Subset

Grants

NCI NIH HHS · CA 14195 · United States

NCI NIH HHS · CA 17289 · United States

NIGMS NIH HHS · GM 07313 · United States

External Links

PubMed source DOI: 10.1128/JVI.42.2.755-759.1982 PMC Full Text View journal details

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Synthesis of coronavirus mRNAs: kinetics of inactivation of infectious bronchitis virus RNA synthesis by UV light.

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