Eukaryotic DNA repair is blocked at different steps by inhibitors of DNA topoisomerases and of DNA polymerases alpha and beta.

Cell Line Colonic Neoplasms Cytarabine/pharmacology DNA Polymerase I/antagonists & inhibitors DNA Polymerase II/antagonists & inhibitors DNA Repair Dideoxynucleosides Humans Kinetics Nalidixic Acid/pharmacology Novobiocin/pharmacology Nucleic Acid Synthesis Inhibitors Thymidine/analogs & derivatives,pharmacology Topoisomerase I Inhibitors

Dideoxynucleosides Nucleic Acid Synthesis Inhibitors Topoisomerase I Inhibitors Cytarabine Novobiocin 2',3'-dideoxythymidine Nalidixic Acid DNA Polymerase I DNA Polymerase II Thymidine