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PMID: 6281771 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Gap junctional conductance: comparison of sensitivities to H and Ca ions.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 2 ·1982-01-00 ·Pages 441-5

Spray DC, Stern JH, Harris AL, Bennett MV

Abstract

One cytoplasmic aspect of the junctional membrane between coupled pairs of Fundulus blastomeres was perfused with solutions of known H and Ca ion concentrations. Conductance of junctional membrane was decreased by either ion. The sensitivity to H ions was about 10,000 times greater than that to Ca ions. The results suggest that junctional conductance can be modulated by changes in H ion concentration near physiological pH, but that unphysiologically high concentrations of Ca ion, such as would be reached only on cell death, are required for comparable changes in junctional conductance.

MeSH Terms
Animals Calcium/physiology Cell Communication Cleavage Stage, Ovum/physiology Electric Conductivity Hydrogen-Ion Concentration Intercellular Junctions/physiology Killifishes/embryology Protons
Chemicals
Protons Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Spray D C
Stern J H
Harris A L
Bennett M V
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23 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.2.441
Published
1982-01-00
Pages
441-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC345759
Subset
IM
Grants
NICHD NIH HHS · HD-02428 · United States
NINDS NIH HHS · NS-07512 · United States
NINDS NIH HHS · NS-12627 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.2.441 PMC Full Text View journal details
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