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PMID: 6280582 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Experimental models of virus-induced demyelination of the central nervous system.

Annals of neurology ·Vol. 11 ·No. 2 ·1982-02-00 ·Pages 109-27

Dal Canto MC, Rabinowitz SG

Abstract

One of the arguments in favor of a viral pathogenesis for multiple sclerosis is the existence of several experimental and natural animal models of virus-induced primary demyelination. This review deals comprehensively with such models. Well-known examples of demyelinating viral infections in their natural host are JHM, Theiler, visna, and canine distemper encephalomyelitides. Recent reports of experimental murine infections with pathogens such as vesicular stomatitis, Chandipura, herpes simplex, Venezuelan equine encephalomyelitis, and Semliki Forest viruses are also discussed. The thrust of the review is to include viral models suspected of producing primary demyelination on an immunopathological basis.

MeSH Terms
Animals Antibodies, Viral/analysis Central Nervous System Diseases/immunology,pathology Coronaviridae Infections/pathology Demyelinating Diseases/immunology,pathology Disease Models, Animal Distemper/pathology Distemper Virus, Canine Dogs Encephalitis Virus, Venezuelan Equine Enterovirus Infections/immunology,pathology Herpes Simplex/immunology,pathology Maus Elberfeld virus/immunology Multiple Sclerosis/immunology,pathology Pneumonia, Progressive Interstitial, of Sheep/immunology,pathology Rhabdoviridae/immunology Sheep Virus Diseases/immunology,pathology Visna-maedi virus
Chemicals
Antibodies, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dal Canto M C
Rabinowitz S G
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77 references, click to expand
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Article Info
Journal
Annals of neurology
Abbr.
Ann Neurol
ISSN
0364-5134
DOI
10.1002/ana.410110202
Published
1982-02-00
Pages
109-27
Language
English
Region
United States
NLM ID
7707449
PMCID
PMC7159566
Subset
IM
Grants
NINDS NIH HHS · NS-13011 · United States
NINDS NIH HHS · NS-13045 · United States
External Links
PubMed source DOI: 10.1002/ana.410110202 PMC Full Text View journal details
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