Home LiteratureArticle Details
PMID: 6276787 Published · ppublish English Journal Article

Involvement of cyclic AMP in the direct inotropic action of amrinone. Biochemical and functional evidence.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 318 ·No. 2 ·1981-12-00 ·Pages 112-20

Honerjäger P, Schäfer-Korting M, Reiter M

Abstract

暂无摘要

MeSH Terms
3',5'-Cyclic-AMP Phosphodiesterases/metabolism Aminopyridines/pharmacology Amrinone Animals Carbachol/pharmacology Cyclic AMP/physiology Drug Interactions Female Guinea Pigs In Vitro Techniques Male Membrane Potentials/drug effects Myocardial Contraction/drug effects Myocardium/enzymology Papillary Muscles/metabolism
Chemicals
Aminopyridines Carbachol Cyclic AMP 3',5'-Cyclic-AMP Phosphodiesterases Amrinone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Honerjäger P
Schäfer-Korting M
Reiter M
References (38)
38 references, click to expand
  1. The time course of changes in cyclic nucleotide levels during cholinergic inhibition of positive inotropic actions of isoprenaline and theophylline in the isolated canine ventricular myocardium.
    Naunyn Schmiedebergs Arch Pharmacol. 1980 Jun;312(2):175-82 PMID: 6250085
  2. Comments on "cardiotonic activity of amrinone-win 40680 [5-amino-3-4'-bypyridin-6(1H)-one]".
    Circ Res. 1980 Jun;46(6):887-8 PMID: 7379253
  3. A simple ultrasensitive method for the assay of cyclic AMP and cyclic GMP in tissues.
    Life Sci. 1976 Mar 1;18(5):529-41 PMID: 176557
  4. Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres.
    J Physiol. 1978 Aug;281:187-208 PMID: 702368
  5. Field stimulation as a means of effecting the graded release of autonomic transmitters in isolated heart muscle.
    J Pharmacol Exp Ther. 1966 Feb;151(2):221-35 PMID: 5932600
  6. Properties of two inward membrane currents in the heart.
    Annu Rev Physiol. 1979;41:413-24 PMID: 373598
  7. Effects of several phosphodiesterase-inhibitors on guinea-pig myocardium.
    Naunyn Schmiedebergs Arch Pharmacol. 1978 Mar;302(1):77-86 PMID: 206845
  8. Cyclic AMP and contractile activity in heart.
    Adv Cyclic Nucleotide Res. 1977;8:363-420 PMID: 21550
  9. Calcium-dependent slow action potentials in potassium-depolarized guinea-pig ventricular myocardium enhanced by barium ions.
    Naunyn Schmiedebergs Arch Pharmacol. 1980;315(1):47-54 PMID: 7242693
  10. GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists.
    Naunyn Schmiedebergs Arch Pharmacol. 1979 Dec;310(2):113-9 PMID: 530317
  11. BIPHASIC ACTION OF ACETYLCHOLINE ON VENTRICULAR MYOCARDIUM.
    Circ Res. 1965 Jun;16:527-36 PMID: 14299505
  12. Interaction of four methylxanthine compounds and norepinephrine on cardiac phosphorylase activation and cardiac contractility.
    Recent Adv Stud Cardiac Struct Metab. 1973;3:261-73 PMID: 4377599
  13. The effects of adrenaline and theophylline on action potential and contraction of mammalian ventricular muscle under "rested-state" and "steady-state" stimulation.
    Naunyn Schmiedebergs Arch Pharmacol. 1977 Dec;301(2):99-107 PMID: 600328
  14. Correlation of cyclic AMP and cyclic GMP levels with changes in contractile force of dog ventricular myocardium during cholinergic antagonism of positive inotropic actions of histamine, glucagon, theophylline and papaverine.
    Jpn J Pharmacol. 1979 Dec;29(6):855-64 PMID: 232199
  15. Effects of amrinone, a cardiotonic drug, on calcium movements in dog erythrocytes.
    J Clin Invest. 1980 Aug;66(2):254-9 PMID: 7400314
  16. Is potassium conductance of cardiac Purkinje fibres controlled by (Ca2+)?
    Nature. 1975 Jan 24;253(5489):273-4 PMID: 1113845
  17. Muscarinic antagonism of the effects of phosphodiesterase inhibitor (methylisobutylxanthine) in embryonic chick ventricle.
    J Pharmacol Exp Ther. 1980 Nov;215(2):348-56 PMID: 6160237
  18. Cardiotonic activity of amrinone--Win 40680 [5-amino-3,4'-bipyridine-6(1H)-one].
    Circ Res. 1979 Nov;45(5):666-77 PMID: 39684
  19. Cardiac actions of glucagon.
    Circ Res. 1968 Jun;22(6):777-87 PMID: 4385510
  20. An improved assay of cyclic 3',5'-nucleotide phosphodiesterases with QAE-Sephadex columns.
    Naunyn Schmiedebergs Arch Pharmacol. 1980 Mar;311(2):193-8 PMID: 6247661
  21. Influence of caffeine and other methylxanthines on mechanical properties of isolated mammalian heart muscle. Evidence for a dual mechanism of action.
    Circ Res. 1972 Apr;30(4):367-92 PMID: 4401230
  22. Amrinone: a new non-glycosidic, non-adrenergic cardiotonic agent effective in the treatment of intractable myocardial failure in man.
    Circulation. 1979 Jun;59(6):1098-104 PMID: 436202
  23. New cardiotonic agents: a search for digitalis substitute.
    Life Sci. 1978 Apr 3-17;22(13-15):1139-47 PMID: 661501
  24. [Evaluation of inotropically active drugs on isolated papillary muscle].
    Arzneimittelforschung. 1967 Oct;17(10):1249-53 PMID: 5632870
  25. The effects of amrinone on contractility, Ca2+ uptake and cAMP in smooth muscle.
    Eur J Pharmacol. 1980 Jan 25;61(2):159-65 PMID: 6243565
  26. Blockade of the positive inotropic actions of epinephrine and theophylline by acetylcholine.
    J Pharmacol Exp Ther. 1967 Nov;158(2):241-7 PMID: 6065146
  27. Interaction between cyclic adenosine monophosphate and cyclic gunaosine monophosphate in guinea pig ventricular myocardium.
    Circ Res. 1975 Sep;37(3):309-17 PMID: 168986
  28. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  29. Effects of amrinone on myocardial energy metabolism and hemodynamics in patients with severe congestive heart failure due to coronary artery disease.
    Circulation. 1980 Jul;62(1):28-34 PMID: 7379283
  30. Hemodynamic assessment of amrinone. A new inotropic agent.
    N Engl J Med. 1978 Dec 21;299(25):1373-7 PMID: 714115
  31. The effects of amrinone on transport and cyclic AMP metabolism in toad urinary bladder.
    J Pharmacol Exp Ther. 1981 Feb;216(2):220-4 PMID: 6257881
  32. Effect of noradrenaline on an early and a late component of the myocardial contraction.
    Naunyn Schmiedebergs Arch Pharmacol. 1978 Oct;305(1):65-74 PMID: 214720
  33. Direct vasodilator and positive inotropic actions of amrinone.
    J Mol Cell Cardiol. 1980 Jun;12(6):647-52 PMID: 7452740
  34. The dependence on contraction frequency of the positive inotropic effect of dihydro-ouabain.
    Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;300(1):1-9 PMID: 593426
  35. Relationship between internal calcium and outward current in mammalian ventricular muscle; a mechanism for the control of the action potential duration?
    J Physiol. 1976 Oct;262(1):15-37 PMID: 994035
  36. Excitation-contraction coupling in cardiac muscle.
    Prog Biophys Mol Biol. 1979;35(1):1-52 PMID: 384460
  37. Slow inward current and its role mediating the chronotropic effect of epinephrine in the rabbit sinoatrial node.
    Pflugers Arch. 1980 Oct;388(1):1-9 PMID: 7192383
  38. The role of cyclic adenosine 3', 5'-monophosphate and calcium in the regulation of contractility and glycogen phosphorylase activity in guinea pig papillary muscle.
    Circ Res. 1976 Sep;39(3):388-95 PMID: 182412
Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
Published
1981-12-00
Pages
112-20
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com