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PMID: 6275277 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

AQA 39*, a new bradycardic agent which blocks myocardial calcium (Ca) channels in a frequency- and voltage-dependent manner.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 317 ·No. 3 ·1981-11-00 ·Pages 228-32

Trautwein W, Pelzer D, McDonald TF, Osterrieder W

Abstract

暂无摘要

MeSH Terms
Action Potentials/drug effects Animals Electric Stimulation Heart/drug effects Heart Rate/drug effects Heart Ventricles/drug effects In Vitro Techniques Ion Channels/metabolism Isoindoles Myocardial Contraction/drug effects Myocardium/metabolism Phthalimides/pharmacology Rabbits
Chemicals
Ion Channels Isoindoles Phthalimides falipamil
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Trautwein W
Pelzer D
McDonald T F
Osterrieder W
References (12)
12 references, click to expand
  1. Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium. III. Effects of the optical isomers on transmembrane action potentials.
    Naunyn Schmiedebergs Arch Pharmacol. 1975;290(1):81-97 PMID: 1178071
  2. Calcium conductance and tension in mammalian ventricular muscle.
    Pflugers Arch. 1975;354(1):55-74 PMID: 1169758
  3. The voltage- and time-dependent effects of (-)-verapamil on the slow inward current in isolated cat ventricular myocardium.
    J Pharmacol Exp Ther. 1978 Oct;207(1):49-55 PMID: 702350
  4. The electrophysiological basis of the bradycardic action of AQA 39 on the sinoatrial node.
    Naunyn Schmiedebergs Arch Pharmacol. 1981 Nov;317(3):233-7 PMID: 6275278
  5. Inward membrane currents in mammalian myocardium.
    Pflugers Arch. 1972;334(1):1-23 PMID: 5066332
  6. Inotropic and electrophysiological actions of verapamil and D 600 in mammalian myocardium. I. Pattern of inotropic effects of the racemic compounds.
    Naunyn Schmiedebergs Arch Pharmacol. 1975;290(1):49-68 PMID: 1178069
  7. Membrane currents in cat myocardium: separation of inward and outward components.
    J Physiol. 1978 Jan;274:193-216 PMID: 624993
  8. Membrane currents underlying activity in frog sinus venosus.
    J Physiol. 1977 Oct;271(3):783-816 PMID: 303699
  9. On the mechanism of slow calcium channel block in heart.
    Pflugers Arch. 1980 May;385(2):175-9 PMID: 6248838
  10. On the mechanism underlying the action of D-600 on slow inward current and tension in mammalian myocardium.
    Circ Res. 1977 Apr;40(4):408-14 PMID: 844153
  11. Slow inward current and its role mediating the chronotropic effect of epinephrine in the rabbit sinoatrial node.
    Pflugers Arch. 1980 Oct;388(1):1-9 PMID: 7192383
  12. Classification of antidysrhythmic drugs.
    Pharmacol Ther B. 1975;1(1):115-38 PMID: 772700
Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00503822
Published
1981-11-00
Pages
228-32
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00503822 View journal details
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