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PMID: 6275124 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic relationship between the Mus cervicolor M432 retrovirus and the Mus Musculus intracisternal type A particle.

Journal of virology ·Vol. 40 ·No. 3 ·1981-12-00 ·Pages 901-11

Callahan R, Kuff EL, Lueders KK, Birkenmeier E

Abstract

The genetic relationship between the retrovirus-like intracisternal type A particle (IAP) from Mus musculus and the novel retrovirus (M432) from M. cervicolor has been determined by heteroduplex and restriction endonuclease analyses of molecular clones of the respective genomes. We have found a major homology region (3.7 kilobase pairs) which probably begins near the 3' end of the M432 gag gene, spans the pol gene, and ends in the env gene. A second region (0.6 kilobase pairs) of weak homology was also observed adjacent to the 3' long terminal repeats of the respective genomes. The IAP genome is well conserved in the cellular DNA of all species of the genus Mus. In contrast, cellular DNA sequences related to the 5' end of the M432 genome, which shares no homology with the IAP genome, are found only in M. cervicolor and the closely related species M. cookii. These results suggest that the infectious M432 retroviral genome arose as a result of a recombinational event(s) between the IAP genome and another, as yet unidentified, class of retrovirus-related sequences or other cellular sequences.

MeSH Terms
Animals Base Sequence Cloning, Molecular DNA DNA Restriction Enzymes DNA, Viral Genes, Viral Mice/genetics Muridae/genetics,microbiology Nucleic Acid Heteroduplexes Recombination, Genetic Retroviridae/genetics
Chemicals
DNA, Viral Nucleic Acid Heteroduplexes DNA DNA Restriction Enzymes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Callahan R
Kuff E L
Lueders K K
Birkenmeier E
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34 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.40.3.901-911.1981
Published
1981-12-00
Pages
901-11
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256701
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.40.3.901-911.1981 PMC Full Text View journal details
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