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PMID: 6274800 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

In vitro infection of murine macrophages with Junin virus.

Infection and immunity ·Vol. 35 ·No. 1 ·1982-01-00 ·Pages 356-8

González PH, Lampuri JS, Coto CE, Laguens RP

Abstract

Mouse peritoneal macrophages were successfully infected with two strains of Junin virus producing high titers with no apparent cell damage. Infected cultures survived longer than noninfected cultures. The pattern of virus release suggested a persistent infection. Virus replication was delayed in macrophages from mice previously immunized with Junin virus. These results support the opinion that macrophages are targets for virus replication in vivo infections.

MeSH Terms

Animals Arenaviridae/growth & development Arenaviruses, New World/growth & development,immunology Ascitic Fluid/cytology Cell Survival Cytoplasm/microbiology Immunization Macrophages/microbiology,physiology Mice Phagocytosis

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

González P H

Lampuri J S

Coto C E

Laguens R P

References (8)

8 references, click to expand

Infection of cultivated mouse peritoneal macrophages with lymphocytic choriomeningitis virus.
J Gen Virol. 1978 Jun;39(3):565-70 PMID: 566306
Interactions between viruses and lymphocytes. I. In vivo replication of lymphocytic choriomeningitis virus in mononuclear cells during both chronic and acute viral infections.
J Immunol. 1978 Oct;121(4):1262-9 PMID: 308960
Infectious lymphocytes in lymphocytic choriomeningitis virus carrier mice.
J Gen Virol. 1979 Mar;42(3):481-92 PMID: 311821
Junin virus infection of guinea pigs: immunohistochemical and ultrastructural studies of hemopoietic tissue.
J Infect Dis. 1981 Jan;143(1):7-14 PMID: 6260868
Protection of guinea pigs inoculated with Tacaribe virus against lethal doses of Junin virus.
J Infect Dis. 1980 Mar;141(3):389-93 PMID: 6245155
Lymphatic tissue in Argentine hemorrhagic fever. Pathologic features.
Arch Pathol Lab Med. 1980 May;104(5):250-4 PMID: 6154445
[Persistent infection of mouse cells with Junin virus: participation of interferon].
Medicina (B Aires). 1980 Sep-Oct;40(5):537-42 PMID: 6163063
Temperature sensitivity of the arenavirus junin isolated from persistently infected Vero cells.
Intervirology. 1979;11(5):282-7 PMID: 222707

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.35.1.356-358.1982

Published

1982-01-00

Pages

356-8

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC351037

Subset

External Links

PubMed source DOI: 10.1128/iai.35.1.356-358.1982 PMC Full Text View journal details

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In vitro infection of murine macrophages with Junin virus.

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