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PMID: 6272723 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Stimulation of inorganic-phosphate incorporation into phosphatidylinositol in rat thoracic aorta mediated through V1-vasopressin receptors.

The Biochemical journal ·Vol. 194 ·No. 1 ·1981-01-15 ·Pages 167-72

Takhar AP, Kirk CJ

Abstract

Vasopressin stimulates the incorporation of [32P]Pi into phosphatidylinositol but not into other phospholipids in rat thoracic aorta strips. The relative abilities of three vasopressin analogues to stimulate phosphatidylinositol labelling in rat aorta are similar to their relative pressor potencies in vivo and to their relative potencies in stimulating the metabolism of rat hepatocytes, but very different from their relative antidiuretic potencies. The vasopressor antagonist [1-(beta-mercapto-beta, beta-cyclopentamethylenepropionic acid),8-arginine]vasopressin competitively inhibits [Arg8]vasopressin-stimulated phosphatidylinositol labelling in rat aorta with a pA2 of 8.1. It is concluded that the Ca2+-mobilizing vasopressin receptors (V1-receptors) of the rat aorta stimulate phosphatidylinositol metabolism, probably by enhancing phosphatidylinositol breakdown.

MeSH Terms
Animals Aorta, Thoracic/metabolism Arginine Vasopressin/analogs & derivatives,pharmacology Dose-Response Relationship, Drug In Vitro Techniques Male Muscle, Smooth, Vascular/drug effects,metabolism Phosphates/metabolism Phosphatidylinositols/biosynthesis Rats Receptors, Cell Surface/metabolism Receptors, Vasopressin Stimulation, Chemical
Chemicals
Phosphates Phosphatidylinositols Receptors, Cell Surface Receptors, Vasopressin Arginine Vasopressin argipressin, beta-mercapto-beta,beta cyclopentamethylenepropionic acid(1)-
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Takhar A P
Kirk C J
References (28)
28 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1940167
Published
1981-01-15
Pages
167-72
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1162729
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1940167 PMC Full Text View journal details
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