Selective inhibition of herpesvirus deoxyribonucleic acid synthesis by acycloguanosine, 2'-fluoro-5-iodo-aracytosine, and (E)-5-(2-bromovinyl)-2'-deoxyuridine.

Antimicrobial agents and chemotherapy ·Vol. 19 ·No. 5 ·1981-05-00 ·Pages 927-9

Larsson A, Oberg B

Abstract

The selectivity of inhibition of herpesvirus deoxyribonucleic acid synthesis by acycloguanosine, 2'-fluoro-5-iodo-aracytosine, and (E)-5-(2-bromovinyl)-2'-deoxyuridine was determined by isopycnic banding of (32)P-labeled deoxyribonucleic acid from herpesvirus-infected and uninfected cells.

MeSH Terms

Acyclovir Animals Antiviral Agents/pharmacology Bromodeoxyuridine/analogs & derivatives,pharmacology Cell Line Chlorocebus aethiops Cytarabine/analogs & derivatives,pharmacology DNA/biosynthesis DNA, Viral/biosynthesis Guanine/analogs & derivatives,pharmacology Kidney Simplexvirus/drug effects,metabolism

Chemicals

Antiviral Agents DNA, Viral Cytarabine brivudine fiacitabine Guanine DNA Bromodeoxyuridine Acyclovir

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Larsson A

Oberg B

References (10)

10 references, click to expand

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5716-20 PMID: 202961
9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.
Nature. 1978 Apr 13;272(5654):583-5 PMID: 205792
The selective inhibition of viral DNA synthesis by chemotherapeutic agents: an indicator of clinical usefulness?
Ann N Y Acad Sci. 1977 Mar 4;284:396-409 PMID: 212984
Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.
J Med Chem. 1979 Jan;22(1):21-4 PMID: 218006
Nucleoside analogs with antiviral activity.
Biochem Pharmacol. 1976 Jun 1;25(11):1233-9 PMID: 938547
Characteristics of herpesvirus mutants resistant to phosphonoformate and phosphonoacetate.
Antimicrob Agents Chemother. 1979 Jun;15(6):758-62 PMID: 475360
Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.
J Virol. 1979 Oct;32(1):72-7 PMID: 232189
2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent.
Antimicrob Agents Chemother. 1980 May;17(5):803-6 PMID: 6249196
Enzymatic targets in virus chemotherapy.
Antibiot Chemother (1971). 1980;27:22-69 PMID: 6996606
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2947-51 PMID: 223163

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.19.5.927

Published

1981-05-00

Pages

927-9

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC181545

Subset

External Links

PubMed source DOI: 10.1128/AAC.19.5.927 PMC Full Text View journal details

Analysis Services

Selective inhibition of herpesvirus deoxyribonucleic acid synthesis by acycloguanosine, 2'-fluoro-5-iodo-aracytosine, and (E)-5-(2-bromovinyl)-2'-deoxyuridine.

Contact

WeChat Official Account