Synthesis of oligonucleotides on cellulose. Part II: Design and synthetic strategy to the synthesis of 22 oligodeoxynucleotides coding for gastric inhibitory polypeptide (GIP).

Nucleic acids symposium series ·No. 7 ·1980-00-00 ·Pages 225-32

Horn T, Vasser MP, Struble ME, Crea R

Abstract

A solid-phase approach using trinucleotide building blocks and functionalized cellulose as solid support was used to synthesize the 22 oligodeoxynucleotides that constitute a totally synthetic gene coding for a 43 amino acid peptide. Gastric inhibitory Polypeptide. The overall strategy used for the design and synthesis of the oligomers is described.

MeSH Terms

Amino Acid Sequence Base Sequence Cellulose Codon DNA Restriction Enzymes Gastric Inhibitory Polypeptide/genetics Gastrointestinal Hormones/genetics Humans Indicators and Reagents Methods Oligodeoxyribonucleotides/chemical synthesis Oligonucleotides/chemical synthesis

Chemicals

Codon Gastrointestinal Hormones Indicators and Reagents Oligodeoxyribonucleotides Oligonucleotides Gastric Inhibitory Polypeptide Cellulose DNA Restriction Enzymes

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Horn T

Vasser M P

Struble M E

Crea R

Article Info

Journal

Nucleic acids symposium series

Abbr.

Nucleic Acids Symp Ser

ISSN

0261-3166

Published

1980-00-00

Pages

225-32

Language

English

Region

England

NLM ID

8007206

Subset

External Links

PubMed source

Analysis Services

Synthesis of oligonucleotides on cellulose. Part II: Design and synthetic strategy to the synthesis of 22 oligodeoxynucleotides coding for gastric inhibitory polypeptide (GIP).

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