The phosphatidylinositol cycle and the regulation of arachidonic acid production.

Nature ·Vol. 292 ·No. 5821 ·1981-07-23 ·Pages 367-9

Lapetina EG, Billah MM, Cuatrecasas P

Abstract

暂无摘要

MeSH Terms

Animals Arachidonic Acid Arachidonic Acids/blood Blood Platelets/drug effects,metabolism Bucladesine/pharmacology Calcimycin/pharmacology Calcium Chloride/pharmacology Horses Kinetics Phosphatidic Acids/blood Phosphatidylinositols/blood Quinacrine/pharmacology Thrombin/pharmacology

Chemicals

Arachidonic Acids Phosphatidic Acids Phosphatidylinositols Arachidonic Acid Calcimycin Bucladesine Thrombin Quinacrine Calcium Chloride

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Lapetina E G

Billah M M

Cuatrecasas P

References (25)

25 references, click to expand

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Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.
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Cyclic AMP inhibits synthesis of prostaglandin endoperoxide (PGG2) in human platelets.
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Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin.
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Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.
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Thrombin, collagen and A23187 stimulated endogenous platelet arachidonate metabolism: differential inhibition by PGE1, local anesthetics and a serine-protease inhibitor.
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Serine esterase inhibitors block stimulus-induced mobilization of arachidonic acid and phosphatidylinositide-specific phospholipase C activity in platelets.
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Cyclic adenosine 3',5'-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets.
Biochem Biophys Res Commun. 1977 Jun 6;76(3):828-35 PMID: 197928
Phosphatidylinositol-specific phospholipase-C of platelets: association with 1,2-diacyglycerol-kinase and inhibition by cyclic-AMP.
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Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/292367a0

Published

1981-07-23

Pages

367-9

Language

English

Region

England

NLM ID

0410462

PMCID

PMC7094967

Subset

External Links

PubMed source DOI: 10.1038/292367a0 PMC Full Text View journal details

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The phosphatidylinositol cycle and the regulation of arachidonic acid production.

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