alpha 1-adrenoceptors can mediate chronotropic responses in the rat heart.

British journal of pharmacology ·Vol. 73 ·No. 3 ·1981-07-00 ·Pages 586-8

Flavahan NA, McGrath JC

Abstract

In the pithed rat, amidephrine a "selective" alpha 1-adrenoceptor agonist, evokes a positive chronotropic response. This response can be antagonized by prazosin but not by propranolol or by rauwolscine. Similarly, part of the chronotropic response to cardioaccelerator nerve stimulation is resistant to blockade by propranolol but is sensitive to prazosin or WB4101. We conclude that alpha 1-adrenoceptors can mediate a chronotropic response in the rat heart either to exogenous agonists or to the endogenous neurotransmitter noradrenaline.

MeSH Terms

Animals Electric Stimulation Heart Rate/drug effects Male Prazosin/pharmacology Propranolol/pharmacology Rats Receptors, Adrenergic/physiology Receptors, Adrenergic, alpha/physiology

Chemicals

Receptors, Adrenergic Receptors, Adrenergic, alpha Propranolol Prazosin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Flavahan N A

McGrath J C

References (14)

14 references, click to expand

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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1981.tb16791.x

Published

1981-07-00

Pages

586-8

Language

English

Region

England

NLM ID

7502536

PMCID

PMC2071683

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1981.tb16791.x PMC Full Text View journal details

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alpha 1-adrenoceptors can mediate chronotropic responses in the rat heart.

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