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PMID: 6264606 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Plasmid DNA in Treponema pallidum (Nichols): potential for antibiotic resistance by syphilis bacteria.

Science (New York, N.Y.) ·Vol. 213 ·No. 4507 ·1981-07-31 ·Pages 553-5

Norgard MV, Miller JN

Abstract

A plasmid DNA structure (approximate molecular weight = 7.5 X 10(6)) was identified in the human pathogen Treponema pallidum (Nichols). The inability to isolate this plasmid from rabbit host tissue and the total lack of DNA homology of the plasmid with rabbit DNA has confirmed its Treponema pallidum origin. The observation documents a newly recognized and potentially significant genetic capability for Treponema pallidum.

MeSH Terms

Animals Base Sequence DNA Restriction Enzymes DNA, Bacterial/genetics DNA, Recombinant/metabolism Drug Resistance, Microbial Microscopy, Electron Molecular Weight Nucleic Acid Hybridization Plasmids Protein Biosynthesis Rabbits Treponema pallidum/genetics

Chemicals

DNA, Bacterial DNA, Recombinant DNA Restriction Enzymes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Norgard M V

Miller J N

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6264606

Published

1981-07-31

Pages

553-5

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAID NIH HHS · NIAID-12601 · United States

NIAID NIH HHS · NIAID-16692 · United States

External Links

PubMed source DOI: 10.1126/science.6264606 View journal details

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Plasmid DNA in Treponema pallidum (Nichols): potential for antibiotic resistance by syphilis bacteria.

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