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PMID: 6261255 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 12 ·1980-12-00 ·Pages 7390-4

Stockinger H, Pfizenmaier K, Hardt C, Rodt H, Röllinghoff M, Wagner H

Abstract

Fully allogeneic chimeras were able to develop in vitro alloantigen-specific, as well as H-2-restricted, Sendai virus-specific cytotoxic T-lymphocyte (CTL) response. Depending on the immunization regimen used, Sendai virus-specific CTL responses were restricted to the H-2 antigens of either the stem cell donor or the thymus. Similarly, unprimed splenic T cells of normal mice were found to contain CTL-precursor cells that specifically reacted against Sendai virus or trinitrophenyl derivatives in the context of allogeneic major histocompatibility complex determinants that had not been encountered during their thymic differentiation. A frequency analysis of allogeneically versus syngeneically restricted virus-specific CTL precursors present in splenic T cells showed a ratio of about 1 to 6. These results provide evidence that H-2 restriction of trinitrophenyl- or Sendai virus-specific T cells is dictated by the complex type of the antigen-presenting cell and thus appears to be independent of the type of thymus in which the T cells have undergone maturation.

MeSH Terms

Animals Cells, Cultured Cytotoxicity, Immunologic H-2 Antigens Immunity, Cellular Immunologic Memory Lymphocyte Cooperation Mice Parainfluenza Virus 1, Human/immunology Radiation Chimera Spleen/immunology T-Lymphocytes/immunology

Chemicals

H-2 Antigens

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Stockinger H

Pfizenmaier K

Hardt C

Rodt H

Röllinghoff M

Wagner H

References (30)

30 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.77.12.7390

Published

1980-12-00

Pages

7390-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC350509

Subset

External Links

PubMed source DOI: 10.1073/pnas.77.12.7390 PMC Full Text View journal details

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H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.

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