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PMID: 6261114 Published · ppublish English Comparative Study Journal Article Review

Epidermal growth factor receptors.

Molecular and cellular biochemistry ·Vol. 34 ·No. 3 ·1981-02-11 ·Pages 129-52

Adamson ED, Rees AR

Abstract

EGF-Rs are cell membrane glycoproteins of wide distribution. They have not yet been fully characterized or purified but are probably molecules of 170-190,000 mol. wt. in most cells. The growth factor EGF binds and will saturate cell surface receptors with a KA of about 5 X 10(9) M-1 although a receptor class with an affinity in excess of 10(10) M-1 has been detected in some cells. The number of receptors on a cell does not determine the level of its response. Some cell types have receptors which bind EGF, but with no mitogenic response. The ways in which receptor affinity and/or number is modulated are described. This and other evidence is reviewed in a search for a suitable model of a mechanism of action on the cell, which best fits the current data. There is ample evidence that EGF binds to the receptor; that ligand-receptor complexes cluster or aggregate; and then are internalized and degraded, but evidence for a direct connection between internalization and the subsequent mitogenic response is lacking. Good correlations between internalization and mitogenic responses have been observed and developed into a theory of endocytic activation, but there is a body of evidence which cannot be accommodated by this theory. Instead, an alternative model is suggested.

MeSH Terms
Animals Binding Sites/drug effects Cell Membrane/metabolism Cell Transformation, Neoplastic Cell Transformation, Viral DNA/biosynthesis Epidermal Growth Factor/metabolism,pharmacology ErbB Receptors Female Humans Kinetics Models, Biological Molecular Weight Organ Specificity Peptides/metabolism Pregnancy Receptors, Cell Surface/genetics,metabolism Species Specificity Teratoma/metabolism Tissue Distribution Tretinoin/pharmacology
Chemicals
Peptides Receptors, Cell Surface Tretinoin Epidermal Growth Factor DNA ErbB Receptors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Adamson E D
Rees A R
References (119)
119 references, click to expand
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF02359619
Published
1981-02-11
Pages
129-52
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02359619 View journal details
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