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PMID: 6259727 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Mammalian gonadal determination and gametogenesis.

Science (New York, N.Y.) ·Vol. 211 ·No. 4488 ·1981-03-20 ·Pages 1265-71

Gordon JW, Ruddle FH

Abstract

Although a relationship between the X and Y chromosomes and mammalian sexual development has long been recognized, a detailed understanding of this relation is still lacking. Recent advances in somatic cell genetics and recombinant DNA technology should provide the tools for solving this fundamental problem in developmental genetics.

MeSH Terms

Animals Chromosome Mapping Cloning, Molecular DNA/isolation & purification DNA Restriction Enzymes Disorders of Sex Development Female Fertility Genetic Markers H-Y Antigen/genetics Male Mammals/genetics Mice Nucleic Acid Hybridization Oogenesis Ovary/embryology Sex Chromosomes Sex Determination Analysis Sex Differentiation Spermatogenesis Testis/embryology

Chemicals

Genetic Markers H-Y Antigen DNA DNA Restriction Enzymes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Gordon J W

Ruddle F H

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6259727

Published

1981-03-20

Pages

1265-71

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIGMS NIH HHS · 1F32GM07959-01 · United States

NIGMS NIH HHS · GM09966-19 · United States

External Links

PubMed source DOI: 10.1126/science.6259727 View journal details

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