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PMID: 6259499 Published · ppublish English Journal Article

Cell division in normal and transformed cells: the possible role of superoxide and hydrogen peroxide.

Medical hypotheses ·Vol. 7 ·No. 1 ·1981-01-00 ·Pages 21-42

Oberley LW, Oberley TD, Buettner GR

Abstract

A unified theory of cell division is presented. This theory explains the division of both tumor cells and normal cells and involves superoxide radicals, hydrogen peroxide, glucose, cAMP, and cGMP.

MeSH Terms
Animals Cell Division Cell Membrane/physiology Cell Survival Cell Transformation, Neoplastic/metabolism Cyclic AMP/physiology Glucose/metabolism Glycolysis Humans Hydrogen Peroxide/physiology Liver/metabolism Mitochondria/physiology Models, Theoretical Oxygen/physiology Sarcoma, Experimental/physiopathology Superoxides/physiology
Chemicals
Superoxides Hydrogen Peroxide Cyclic AMP Glucose Oxygen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Oberley L W
Oberley T D
Buettner G R
Article Info
Journal
Medical hypotheses
Abbr.
Med Hypotheses
ISSN
0306-9877
DOI
10.1016/0306-9877(81)90018-9
Published
1981-01-00
Pages
21-42
Language
English
Region
United States
NLM ID
7505668
Subset
IM
External Links
PubMed source DOI: 10.1016/0306-9877(81)90018-9 View journal details
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