Antihypertensive activity of N-[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro (MK-421), an orally active converting enzyme inhibitor.

Administration, Oral Angiotensin I/antagonists & inhibitors Angiotensin-Converting Enzyme Inhibitors Animals Antihypertensive Agents/pharmacology,therapeutic use Blood Pressure/drug effects Dipeptides/pharmacology Disease Models, Animal Dogs Drug Therapy, Combination Enalapril Female Hydrochlorothiazide/therapeutic use Hypertension/drug therapy Hypertension, Renal/drug therapy Male Nephrectomy Rats Renin/blood

Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents Dipeptides Hydrochlorothiazide Enalapril Angiotensin I Renin