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PMID: 6259203 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Human infective dose determinations for oral poliovirus type 1 vaccine in infants.

Journal of clinical microbiology ·Vol. 13 ·No. 2 ·1981-02-00 ·Pages 388-9

Minor TE, Allen CI, Tsiatis AA, Nelson DB, D'Alessio DJ

Abstract

The 50, 10, and 1% human infective doses of poliovirus type 1 vaccine administered orally to 32 infants were estimated to be 72, 39, and 20 tissue culture infective doses, respectively.

MeSH Terms
Feces/microbiology Humans Infant Poliovirus/isolation & purification Poliovirus Vaccine, Oral/administration & dosage Vaccines, Attenuated/administration & dosage
Chemicals
Poliovirus Vaccine, Oral Vaccines, Attenuated
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Minor T E
Allen C I
Tsiatis A A
Nelson D B
D'Alessio D J
References (7)
7 references, click to expand
  1. Minimal infective dose of attenuated poliovirus for man.
    Am J Public Health Nations Health. 1967 Oct;57(10):1837-40 PMID: 4293371
  2. Counterimmunoelectrophoresis test for immunoglobulin M antibodies to group B coxsackievirus.
    J Clin Microbiol. 1979 Apr;9(4):503-6 PMID: 222806
  3. Living attenuated poliomyelitis virus as an immunizing agent of man.
    S Afr Med J. 1955 Oct 29;29(49):1134-42 PMID: 13281666
  4. Immunization against poliomyelitis with living attenuated virus.
    Am J Trop Med Hyg. 1956 May;5(3):440-52 PMID: 13327178
  5. Present status of attenuated live-virus poliomyelitis vaccine.
    J Am Med Assoc. 1956 Dec 29;162(18):1589-96 PMID: 13376323
  6. Clinical trials in infants of orally administered attenuated poliomyelitis viruses.
    Pediatrics. 1959 Jun;23(6):1041-62 PMID: 13657588
  7. Clinical investigations on attenuated strains of poliomyelitis virus; use as a method of immunization of children with living virus.
    J Am Med Assoc. 1956 Mar 17;160(11):954-66 PMID: 13295050
Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/jcm.13.2.388-389.1981
Published
1981-02-00
Pages
388-9
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC273794
Subset
IM
External Links
PubMed source DOI: 10.1128/jcm.13.2.388-389.1981 PMC Full Text View journal details
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