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PMID: 6255162 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Action of glucosamine on acetylcholine-sensitive channels.

The Journal of membrane biology ·Vol. 56 ·No. 1 ·1980-08-21 ·Pages 43-8

Marchais D, Marty A

Abstract

The action of glucosamine was studied on voltage clamped neurones of Aplysia, presenting an excitatory response to acetylcholine. Noise and relaxation experiments show that glucosamine increases the mean channel open time and reduces the amplitude of the elementary current associated with the acetylcholine response. Both effects are enhanced by hyperpolarization of the cell membrane. The results are interpreted by a model assuming glucosamine binding to open channels. This binding impedes the flow of permeant ions and decreases the closing rate of the channels.

MeSH Terms
Acetylcholine/physiology Action Potentials/drug effects Animals Aplysia Glucosamine/pharmacology In Vitro Techniques Ion Channels/metabolism Mathematics Models, Biological Neural Conduction/drug effects Neurons/metabolism,physiology Sodium/metabolism
Chemicals
Ion Channels Sodium Glucosamine Acetylcholine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Marchais D
Marty A
References (23)
23 references, click to expand
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Article Info
Journal
The Journal of membrane biology
Abbr.
J Membr Biol
ISSN
0022-2631
DOI
10.1007/BF01869350
Published
1980-08-21
Pages
43-8
Language
English
Region
United States
NLM ID
0211301
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01869350 View journal details
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