Transformation by cloned Harvey murine sarcoma virus DNA: efficiency increased by long terminal repeat DNA.

Science (New York, N.Y.) ·Vol. 210 ·No. 4475 ·1980-12-12 ·Pages 1249-51

Chang EH, Ellis RW, Scolnick EM, Lowy DR

Abstract

The coding sequences for the transforming (src) protein (p21) of Harvey murine sarcoma virus have been localized to a 1.3 kilobase pair segment near the 5' end of the viral genome. Ligation of the viral terminal repeat DNA to the left end of the src region DNA markedly enhanced the low transforming efficiency of the src region DNA.

MeSH Terms

Cell Transformation, Viral Cloning, Molecular DNA, Viral/genetics Genes, Viral Repetitive Sequences, Nucleic Acid Sarcoma Viruses, Murine/genetics Transformation, Genetic Viral Proteins/genetics

Chemicals

DNA, Viral Viral Proteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Chang E H

Ellis R W

Scolnick E M

Lowy D R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6254153

Published

1980-12-12

Pages

1249-51

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.6254153 View journal details

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Transformation by cloned Harvey murine sarcoma virus DNA: efficiency increased by long terminal repeat DNA.

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