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PMID: 6254143 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors.

Science (New York, N.Y.) ·Vol. 210 ·No. 4468 ·1980-10-00 ·Pages 441-3

Harden TK, Cotton CU, Waldo GL, Lutton JK, Perkins JP

Abstract

Incubation of astrocytoma cells with catecholamines results in a decrease in catecholamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate beta-adrenergic receptors. The altered receptors exhibit agonist binding properties similar to those of receptors that are "uncoupled" from adenylate cyclase.

MeSH Terms

Adenylyl Cyclases/metabolism Astrocytoma Cell Line Centrifugation, Density Gradient Concanavalin A/pharmacology Endocytosis Humans Isoproterenol/metabolism Protein Conformation Receptors, Adrenergic/metabolism Receptors, Adrenergic, beta/metabolism Time Factors

Chemicals

Receptors, Adrenergic Receptors, Adrenergic, beta Concanavalin A Adenylyl Cyclases Isoproterenol

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Harden T K

Cotton C U

Waldo G L

Lutton J K

Perkins J P

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6254143

Published

1980-10-00

Pages

441-3

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIGMS NIH HHS · GM 25163 · United States

NHLBI NIH HHS · HL 22490 · United States

External Links

PubMed source DOI: 10.1126/science.6254143 View journal details

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Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors.

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