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PMID: 6252926 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Collagenase immunolocalization studies of cutaneous secondary melanomas.

British journal of cancer ·Vol. 42 ·No. 2 ·1980-08-00 ·Pages 260-5

Woolley DE, Grafton CA

Abstract

Immunoreactive collagenase has been demonstrated in 5/14 specimens of cutaneous secondary melanomas. In contrast, very little enzyme was seen in 10 specimens of normal human skin. All specimens were fixed within minutes of excision. These findings support the hypothesis that collagenase facilitates connective-tissue breakdown which is associated with tumour invasiveness and metastatic spread.

MeSH Terms

Fluorescent Antibody Technique Humans Melanoma/enzymology,secondary Microbial Collagenase/metabolism Neoplasm Recurrence, Local Skin/enzymology Skin Neoplasms/enzymology,secondary

Chemicals

Microbial Collagenase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Woolley D E

Grafton C A

References (8)

8 references, click to expand

Collagenolytic enzymes in human neoplasms.
Cancer Res. 1972 May;32(5):993-6 PMID: 4622841
Purification and characterization of a collagenase extracted from rabbit tumours.
Biochem J. 1975 Oct;152(1):131-42 PMID: 2161
Degradation of basement membrane by murine tumor cells.
J Natl Cancer Inst. 1977 May;58(5):1427-31 PMID: 192901
Collagenase at sites of cartilage erosion in the rheumatoid joint.
Arthritis Rheum. 1977 Jul-Aug;20(6):1231-9 PMID: 71152
Quantitation and immunocytochemical localization of human skin collagenase in basal cell carcinoma.
J Invest Dermatol. 1977 Oct;69(4):363-7 PMID: 198478
Collagenolytic activities of cultured human malignant melanoma cells.
J Biochem. 1978 Nov;84(5):1171-6 PMID: 215592
Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.
Proc Natl Acad Sci U S A. 1979 May;76(5):2268-72 PMID: 221920
Collagenase production by rheumatoid synovial cells: morphological and immunohistochemical studies of the dendritic cell.
Ann Rheum Dis. 1979 Jun;38(3):262-70 PMID: 226011

Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1980.225

Published

1980-08-00

Pages

260-5

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2010383

Subset

External Links

PubMed source DOI: 10.1038/bjc.1980.225 PMC Full Text View journal details

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