Myeloproliferative virus, a cloned murine sarcoma virus with spleen focus-forming properties in adult mice.

Journal of virology ·Vol. 33 ·No. 2 ·1980-02-00 ·Pages 573-82

Ostertag W, Vehmeyer K, Fagg B, Pragnell IB, Paetz W, Le Bousse MC, Smadja-Joffe F, Klein B, Jasmin C, Eisen H

Abstract

Myeloproliferative virus, derived from Moloney sarcoma virus, causes erythroleukemia and myeloid leukemia in adult mice. This virus is also capable of fibroblast transformation in vitro. The virus consists of two separable biological entities which have been cloned. The helper virus component caused no visible changes in adult mice, whereas the defective virus induced both spleen focus formation and a large increase in erythroid precursor cells but retained the sarcoma virus property of transforming fibroblasts in vitro. Thus, myeloproliferative virus is the first murine sarcoma virus which induces erythroleukemia in adult animals.

MeSH Terms

Animals Bone Marrow Cells Cell Transformation, Viral Cells, Cultured Defective Viruses/growth & development Erythropoietin/pharmacology Fibroblasts/microbiology Helper Viruses/physiology Leukemia, Erythroblastic, Acute/etiology Leukemia, Experimental/etiology Leukemia, Myeloid/etiology Mice Mice, Inbred Strains Rats Sarcoma Viruses, Murine/genetics,growth & development Spleen/microbiology Virus Cultivation

Chemicals

Erythropoietin

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Ostertag W

Vehmeyer K

Fagg B

Pragnell I B

Paetz W

Le Bousse M C

Smadja-Joffe F

Klein B

Jasmin C

Eisen H

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24 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.33.2.573-582.1980

Published

1980-02-00

Pages

573-82

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC288581

Subset

External Links

PubMed source DOI: 10.1128/JVI.33.2.573-582.1980 PMC Full Text View journal details

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Myeloproliferative virus, a cloned murine sarcoma virus with spleen focus-forming properties in adult mice.

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