Cyclic nucleotide elevation preceding catecholamine release in isolated dog adrenals.

Archives internationales de pharmacodynamie et de therapie ·Vol. 245 ·No. 2 ·1980-06-00 ·Pages 262-70

Tsujimoto A, Morita K, Nishikawa T, Yamada S

Abstract

Acetylcholine caused the rapid elevation of cAMP and cGMP levels with a peak within 30 sec in the medulla and in the perfusate preceding catecholamine release in isolated perfused dog adrenal glands. These responses to ACh were completely blocked by hexamethonium plus atropine. A functional role of cyclic nucleotides in catecholamine secretion mechanisms is discussed.

MeSH Terms

Acetylcholine/pharmacology Adrenal Glands/drug effects,metabolism Animals Atropine/pharmacology Catecholamines/metabolism Cyclic AMP/metabolism Cyclic GMP/metabolism Dogs Female Hexamethonium Compounds/pharmacology In Vitro Techniques Male Perfusion

Chemicals

Catecholamines Hexamethonium Compounds Atropine Cyclic AMP Cyclic GMP Acetylcholine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Tsujimoto A

Morita K

Nishikawa T

Yamada S

Article Info

Journal

Archives internationales de pharmacodynamie et de therapie

Abbr.

Arch Int Pharmacodyn Ther

ISSN

0003-9780

Published

1980-06-00

Pages

262-70

Language

English

Region

Belgium

NLM ID

0405353

Subset

External Links

PubMed source View journal details

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Cyclic nucleotide elevation preceding catecholamine release in isolated dog adrenals.

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