Cervical carcinoma: detection of herpes simplex virus RNA in cells undergoing neoplastic change.

International journal of cancer ·Vol. 25 ·No. 1 ·1980-01-15 ·Pages 1-8

McDougall JK, Galloway DA, Fenoglio CM

Abstract

3H-HSV-2 DNA has been hybridized in situ to frozen sectioned tissue from human cervical biopsies. RNA complementary to the virus-specific probe was detected in cells undergoing pre-malignant changes, but not in the cells of the fully developed squamous-cell cancer.

MeSH Terms

Animals Cell Transformation, Neoplastic/analysis Chick Embryo DNA, Viral Female Genes, Viral Humans In Vitro Techniques Nucleic Acid Hybridization RNA, Viral/analysis Simplexvirus Uterine Cervical Neoplasms/analysis

Chemicals

DNA, Viral RNA, Viral

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

McDougall J K

Galloway D A

Fenoglio C M

Article Info

Journal

International journal of cancer

Abbr.

Int J Cancer

ISSN

0020-7136

DOI

10.1002/ijc.2910250102

Published

1980-01-15

Pages

1-8

Language

English

Region

United States

NLM ID

0042124

Subset

External Links

PubMed source DOI: 10.1002/ijc.2910250102 View journal details

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Cervical carcinoma: detection of herpes simplex virus RNA in cells undergoing neoplastic change.

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