Antibody-mediated neutralization of virus is abrogated by mycoplasma.

Infection and immunity ·Vol. 28 ·No. 3 ·1980-06-00 ·Pages 649-53

Dickson C, Elkington J, Hales A, Weiss R

Abstract

The ability of a mouse mammary tumor cell line to abrogate antibody neutralization of vesicular stomatitis virus was shown to be due to the presence of mycoplasma. The mycoplasma was isolated from the cell line and typed as Mycoplasma orale. Colonies of this mycoplasma were used to deliberately infect cell cultures which then gained the capacity to reactivate antibody-neutralized virus. The extent of the reactivation depended on the source of neutralizing antiserum. Other species of mycoplasma were tested and were found to reactivate neutralized virus, indicating that this may be a general phenomenon of mycoplasma contamination.

MeSH Terms

Animals Antibodies, Viral/immunology Antigen-Antibody Reactions Cell Line Mink Mycoplasma/isolation & purification,physiology Neutralization Tests Vesicular stomatitis Indiana virus/growth & development,immunology Virus Activation

Chemicals

Antibodies, Viral

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Dickson C

Elkington J

Hales A

Weiss R

References (13)

13 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.28.3.649-653.1980

Published

1980-06-00

Pages

649-53

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC550999

Subset

External Links

PubMed source DOI: 10.1128/iai.28.3.649-653.1980 PMC Full Text View journal details

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Antibody-mediated neutralization of virus is abrogated by mycoplasma.

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