Home LiteratureArticle Details
PMID: 6249476 Published · ppublish English Journal Article

Production of tumors in hamsters by cells of a pig uterine tube line.

Canadian journal of comparative medicine : Revue canadienne de medecine comparee ·Vol. 44 ·No. 1 ·1980-01-00 ·Pages 77-86

Bouillant AM, Bundza A, Genest P, Greig AS

Abstract

Tumorigenicity was investigated in a pig established cell line continuously subcultured more than 400 times. Tumors were not found in hamsters' cheek pouches inoculated with cells from the first 200 subcultures. Fibroma developed in five out of 13 animals (9/26 pouches) inoculated with cells of the 313th and 314th subcultures. Two chromosome markers were found in the 290th subculture, in the 313th subculture inoculum and in tumor cells.

MeSH Terms
Animals Cell Line Cricetinae Culture Techniques Fallopian Tubes Female Fibroma/etiology,ultrastructure Karyotyping Male Neoplasms, Experimental/etiology,ultrastructure Retroviridae/ultrastructure Swine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bouillant A M
Bundza A
Genest P
Greig A S
References (25)
25 references, click to expand
  1. "Spontaneous" neoplastic transformation of cells in vitro: some facts and theories.
    Natl Cancer Inst Monogr. 1967 Sep;26:387-418 PMID: 4294468
  2. Anchorage and growth regulation in normal and virus-transformed cells.
    Int J Cancer. 1968 Sep 15;3(5):683-93 PMID: 5749478
  3. RNA-dependent DNA polymerase in virions of RNA tumour viruses.
    Nature. 1970 Jun 27;226(5252):1209-11 PMID: 4316300
  4. Growth characteristics of virus-transformed cells. Maximum population density, inhibition by normal cells, serum requirement, growth in soft agar, and xenogeneic transplantability.
    J Exp Med. 1970 Apr 1;131(4):863-79 PMID: 4317881
  5. Virus-like particles occurring in cultures of stable pig kidney cell lines. Brief report.
    Arch Gesamte Virusforsch. 1970;30(4):401-4 PMID: 4195629
  6. C-type virus particles in pig kidney cell lines.
    J Gen Virol. 1971 Feb;10(2):195-8 PMID: 4324256
  7. Development of invasive tumors in the "nude" mouse after injection of cultured human melanoma cells.
    J Natl Cancer Inst. 1972 May;48(5):1531-3 PMID: 5030962
  8. Mammalian cells in culture frequently release type C viruses.
    Science. 1973 Oct 5;182(4107):56-9 PMID: 4125845
  9. Biological characterization of a cell line derived from the pig oviduct.
    In Vitro. 1973 Sep-Oct;9(2):92-102 PMID: 4586534
  10. C-type particles produced by a permanent cell line from a leukemic pig. I. Origin and properties of the host cells and some evidence for the occurrence of C-type-like particles.
    Virology. 1974 Jan;57(1):175-8 PMID: 4362022
  11. Characterization of a type C virus released from the porcine cell line PK(15).
    Virology. 1974 Mar;58(1):65-74 PMID: 4132403
  12. Titration and neutralization of rabies virus (ERA strain) following its replication in a pig fallopian tube cell line.
    Can J Comp Med. 1974 Apr;38(2):118-23 PMID: 4132964
  13. The karyotype of the pig.
    Hereditas. 1974;77(1):149-58 PMID: 4137983
  14. Biologic manifestations of oncogenesis in vitro: a critique.
    J Natl Cancer Inst. 1974 Nov;53(5):1481-5 PMID: 4610171
  15. The case for a family of reverse transcriptase viruses: Retraviridae.
    Intervirology. 1974;4(4):201-6 PMID: 4142632
  16. Type C virus production by a continuous line of pig oviduct cells (PFT).
    J Gen Virol. 1975 May;27(2):173-80 PMID: 49396
  17. Biologic and immunologic properties of porcine type C viruses.
    Virology. 1975 Aug;66(2):616-9 PMID: 50668
  18. Viral susceptibility of a cell line derived from the pig oviduct.
    Can J Comp Med. 1975 Oct;39(4):450-6 PMID: 169971
  19. Growth characteristics of a cell line derived from the pig oviduct.
    Can J Microbiol. 1975 Dec;21(12):2094-7 PMID: 3274
  20. Tumor heterogeneity and the biology of cancer invasion and metastasis.
    Cancer Res. 1978 Sep;38(9):2651-60 PMID: 354778
  21. Cell ultrastructure during the development and the transformation of a pig--uterine tube cell line.
    Am J Vet Res. 1979 Aug;40(8):1140-8 PMID: 294157
  22. Evidence of a mixed population from uterine tube epithelium in a continuous line of pig cells.
    Am J Vet Res. 1979 Aug;40(8):1149-55 PMID: 294158
  23. A new technique for the simultaneous demonstration of lipid and acid polysaccharides on the same tissue section.
    J Histochem Cytochem. 1959 Mar;7(2):101-6 PMID: 13664947
  24. Assessment of potential malignancy of cultured cells: further observations on the differentiation of "normal" and "neoplastic" cells maintained in vitro by hetero-transplantation in Syrian hamsters.
    Natl Cancer Inst Monogr. 1962 Apr;7:173-204 PMID: 13893827
  25. AGAR SUSPENSION CULTURE FOR THE SELECTIVE ASSAY OF CELLS TRANSFORMED BY POLYOMA VIRUS.
    Virology. 1964 Jun;23:291-4 PMID: 14187925
Article Info
Journal
Canadian journal of comparative medicine : Revue canadienne de medecine comparee
Abbr.
Can J Comp Med
ISSN
0008-4050
Published
1980-01-00
Pages
77-86
Language
English
Region
Canada
NLM ID
0151747
PMCID
PMC1320037
Subset
IM
External Links
PubMed source PMC Full Text
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2