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PMID: 6242420 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Chemosensitivity tests by a miniclone technique.

Medical oncology and tumor pharmacotherapy ·Vol. 1 ·No. 1 ·1984-00-00 ·Pages 19-23

Pontén J, Larson A, Lindström M

Abstract

A modified miniclone method has been adopted to tissue culture testing of sensitivity to cytostatic drugs. The technique permits detailed microscopic clonal analysis of multiplication of single cells under conditions of 100% plating efficiency of certain selected established tumor lines or normal cells. Three different response parameters were distinguished--cytolysis, cytostasis and replicative capacity of cell fraction capable of multiplication. Notable differences were found among the five drugs tested--adriamycin, alkeran, BCNU, platinol and streptozocin.

MeSH Terms
Antineoplastic Agents/pharmacology Carmustine/pharmacology Cell Survival/drug effects Cisplatin/pharmacology Colony-Forming Units Assay Dose-Response Relationship, Drug Doxorubicin/pharmacology Humans Melphalan/pharmacology Methods Streptozocin/pharmacology Tumor Stem Cell Assay
Chemicals
Antineoplastic Agents Streptozocin Doxorubicin Cisplatin Melphalan Carmustine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pontén J
Larson A
Lindström M
References (5)
5 references, click to expand
  1. An improved nutrient solution for diploid Chinese hamster and human cell lines.
    Exp Cell Res. 1963 Feb;29:515-26 PMID: 13952250
  2. The usefulness of human tumor cell lines in the study of chemosensitivity. A study of malignant melanomas.
    Int J Cancer. 1981 Oct 15;28(4):403-8 PMID: 7309286
  3. Proliferation control in cloned normal and malignant human cells.
    Exp Cell Res. 1980 Oct;129(2):367-75 PMID: 7428827
  4. Primary bioassay of human tumor stem cells.
    Science. 1977 Jul 29;197(4302):461-3 PMID: 560061
  5. Growth control in miniclones of human glial cells.
    Exp Cell Res. 1978 Feb;111(2):295-9 PMID: 342256
Article Info
Journal
Medical oncology and tumor pharmacotherapy
Abbr.
Med Oncol Tumor Pharmacother
ISSN
0736-0118
DOI
10.1007/BF02935321
Published
1984-00-00
Pages
19-23
Language
English
Region
England
NLM ID
8405039
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02935321
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