In vitro activities of norfloxacin and ciprofloxacin against Mycobacterium tuberculosis, M. avium complex, M. chelonei, M. fortuitum, and M. kansasii.

Antimicrobial agents and chemotherapy ·Vol. 26 ·No. 1 ·1984-07-00 ·Pages 94-6

Gay JD, DeYoung DR, Roberts GD

Abstract

The activities of ciprofloxacin and norfloxacin against 100 mycobacteria isolates were studied in vitro by the 1% standard proportion method. Ciprofloxacin was more active against M. tuberculosis and M. fortuitum with MICs of 1.0 and 0.25 microgram/ml, respectively, against 90% of isolates; norfloxacin had MICs of 8.0 and 2.0 micrograms/ml, respectively, against 90% of isolates.

MeSH Terms

Anti-Bacterial Agents/pharmacology Antitubercular Agents/pharmacology Ciprofloxacin Drug Interactions Microbial Sensitivity Tests Mycobacterium avium/drug effects Mycobacterium tuberculosis/drug effects Nalidixic Acid/analogs & derivatives,pharmacology Norfloxacin Quinolines/pharmacology

Chemicals

Anti-Bacterial Agents Antitubercular Agents Quinolines Nalidixic Acid Ciprofloxacin Norfloxacin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Gay J D

DeYoung D R

Roberts G D

References (17)

17 references, click to expand

Nontuberculous mycobacteria and associated diseases.
Am Rev Respir Dis. 1979 Jan;119(1):107-59 PMID: 369415
In vitro susceptiiblity of Mycobacterium fortuitum and Mycobacterium chelonei to amikacin.
J Infect Dis. 1978 Mar;137(3):318-21 PMID: 632627
Long-term results of medical treatment in Mycobacterium intracellulare infection.
Am J Med. 1979 Sep;67(3):449-53 PMID: 474589
Disk diffusion testing of susceptibility of Mycobacterium fortuitum and Mycobacterium chelonei to antibacterial agents.
Antimicrob Agents Chemother. 1979 Nov;16(5):611-4 PMID: 526002
Identification of clinical isolates of mycobacteria with gas-liquid chromatography alone.
J Clin Microbiol. 1979 Oct;10(4):506-14 PMID: 118984
In vitro susceptibility of Mycobacterium fortuitum to cefoxitin.
Antimicrob Agents Chemother. 1981 Jan;19(1):205-7 PMID: 7247358
Comparative in vitro activity of Mk-0366 and other selected oral antimicrobial agents against Neisseria gonorrhoeae.
Antimicrob Agents Chemother. 1981 Aug;20(2):265-6 PMID: 6456692
Comparison of the antibacterial activity of norfloxacin (MK 0366, AM 715), a new organic acid, with that of other orally absorbed chemotherapeutic agents.
Infection. 1982 Jan;10(1):41-4 PMID: 6461606
Sulfonamide activity against Mycobacterium fortuitum and Mycobacterium chelonei.
Rev Infect Dis. 1981 Sep-Oct;3(5):898-904 PMID: 7339821
In vitro antibacterial activity of norfloxacin (MK-0366).
Antimicrob Agents Chemother. 1982 Apr;21(4):604-7 PMID: 6211139
Comparative in vitro activity of norfloxacin (MK-0366) and ten other oral antimicrobial agents against urinary bacterial isolates.
Antimicrob Agents Chemother. 1982 May;21(5):848-51 PMID: 6213200
Norfloxacin and the antibacterial gamma pyridone beta carboxylic acids.
J Antimicrob Chemother. 1982 Jul;10(1):25-30 PMID: 6213593
In vitro activity of ciprofloxacin, norfloxacin and nalidixic acid.
Eur J Clin Microbiol. 1983 Apr;2(2):111-5 PMID: 6222896
Comparative in vitro activity of norfloxacin against urinary tract pathogens.
Eur J Clin Microbiol. 1983 Jun;2(3):235-41 PMID: 6224679
Pharmacokinetics of norfloxacin in healthy volunteers and patients with renal and hepatic damage.
Eur J Clin Microbiol. 1983 Jun;2(3):253-9 PMID: 6224683
Rapidly growing mycobacteria: testing of susceptibility to 34 antimicrobial agents by broth microdilution.
Antimicrob Agents Chemother. 1982 Aug;22(2):186-92 PMID: 6927280
Pulmonary mycobacterial infections due to Mycobacterium intracellulare-avium complex. Clinical features and course in 100 consecutive cases.
Chest. 1979 Feb;75(2):115-9 PMID: 421545

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.26.1.94

Published

1984-07-00

Pages

94-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC179925

Subset

External Links

PubMed source DOI: 10.1128/AAC.26.1.94 PMC Full Text View journal details

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In vitro activities of norfloxacin and ciprofloxacin against Mycobacterium tuberculosis, M. avium complex, M. chelonei, M. fortuitum, and M. kansasii.

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