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PMID: 6235521 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Internal complementarities in the immune system: regulation of the expression of helper T-cell idiotypes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 14 ·1984-07-00 ·Pages 4520-3

Martinez C, Pereira P, Bernabé R, Bandeira A, Larsson EL, Cazenave PA, Coutinho A

Abstract

More than half of BALB/c helper T lymphocytes specific for 2,4,6-trinitrophenyl (TNP)-modified syngeneic spleen cells are inhibited in their proliferative responses to antigen-presenting cells and in their cooperation with B lymphocytes by monoclonal anti-idiotypic antibodies directed to a TNP-binding BALB/c myeloma protein (MOPC 460). This inhibition is specific for anti-TNP-self helper cells of BALB/c origin and is controlled by IgCh-linked genes, as it is not observed with CB.20 helper cells of the same specificity. In contrast, anti-TNP-self helper cells prepared from BALB/c mice that were chronically suppressed with anti-mu chain antibodies and possessed no B lymphocytes were not inhibited by anti-idiotypic antibodies. We conclude that the B-cell antibody repertoires contribute to the selection of the (idiotypic) T-helper-cell repertoires.

MeSH Terms
Animals Antibodies, Anti-Idiotypic/immunology Antibodies, Monoclonal/immunology B-Lymphocytes/immunology Immunoglobulin Idiotypes Immunoglobulin mu-Chains/immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL T-Lymphocytes, Helper-Inducer/immunology Trinitrobenzenes/pharmacology
Chemicals
Antibodies, Anti-Idiotypic Antibodies, Monoclonal Immunoglobulin Idiotypes Immunoglobulin mu-Chains Trinitrobenzenes sym-trinitrobenzene
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Martinez C
Pereira P
Bernabé R
Bandeira A
Larsson E L
Cazenave P A
Coutinho A
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18 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.14.4520
Published
1984-07-00
Pages
4520-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC345622
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.81.14.4520 PMC Full Text View journal details
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