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PMID: 6231096 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Immunology of metastasis. Can the immune response cope with disseminated tumor?

Cancer metastasis reviews ·Vol. 2 ·No. 3 ·1983-00-00 ·Pages 239-56

Frost P, Kerbel RS

Abstract

The application of immunologic methods to the treatment of neoplasia has been a goal of research in tumor immunology. Unfortunately, no clearly defined success for such therapy has been achieved. However, the most recent advances in tumor biology have provided for a more valid conceptual framework upon which to plan further research in this area. The more general awareness of tumor progression and heterogeneity, particularly in the context of tumor metastasis, while imposing a sense of gloom regarding all therapeutic modalities, shifted immunologic thinking toward the development of nonspecific modalities. We herein propose that this 'shift' may be premature and that immunotherapy using cytolygic T cells could still be feasible. Our views are based on newer approaches for selecting immunogenic variants of malignant tumors and a better understanding of the relationship of the immune response to metastases.

MeSH Terms
Animals Antigens, Neoplasm/immunology Cell Line Humans Immunity, Cellular Immunosuppression Therapy Neoplasm Metastasis Neoplasm Transplantation Neoplasms/immunology,pathology T-Lymphocytes, Cytotoxic/immunology T-Lymphocytes, Regulatory/immunology
Chemicals
Antigens, Neoplasm
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Frost P
Kerbel R S
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Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00048480
Published
1983-00-00
Pages
239-56
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
Grants
NCI NIH HHS · CA 28060 · United States
External Links
PubMed source DOI: 10.1007/BF00048480 View journal details
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