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PMID: 623101 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Efficiency and robustness of pedigree segregation analysis.

American journal of human genetics ·Vol. 30 ·No. 1 ·1978-01-00 ·Pages 28-37

Go RC, Elston RC, Kaplan EB

Abstract

Different pedigree structures and likelihoods are examined to determine their efficiency for parameter estimation under one-locus models. For the cases simulated, family size has little effect; estimates based on unconditional likelihoods are generally more efficient than those based on conditional likelihoods. The proposed method of pedigree analysis under a one-locus model is found to be robust in the analysis of nuclear families: skewness of the data and polygenic inheritance will not lead to the spurious detection of major loci unless they occur simultaneously, and together with a moderate amount of environmental correlation among sibs.

MeSH Terms
Gene Frequency Humans Mathematics Models, Biological Pedigree
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Go R C
Elston R C
Kaplan E B
References (11)
11 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1978-01-00
Pages
28-37
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685454
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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