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题目:: Small, resting B cells can be induced to proliferate by direct signals from activated helper T cells.
作者:: Clement(L T),Dagg(M K),Gartland(G L)
状态:: 发布时间1984-02-23 , 更新时间 2007-11-14
期刊:: J Immunol
摘要:: We have investigated the role of T lymphocytes in the activation of small, resting B cells. Homogeneous populations of small human B cells were purified with a fluorescence-activated cell sorter by positive and negative immunofluorescent staining techniques. When these small B cells were cultured with mitogen-activated Leu-3+ T cells, significant B cell proliferation was observed. This T cell-dependent B cell proliferative response did not require cross-linkage of B cell surface immunoglobulin molecules or B cell exposure to the mitogens employed for T cell activation. Culture supernatants from activated helper T cells could neither induce small B cell proliferation nor augment the B cell response observed with limiting numbers of T cells. These data indicate that activated helper T cells can provide all the signals required for the activation and proliferation of small, resting B cells and suggest that direct T-B cell contact is a critical element for this T-B cell interaction.
语言:: eng
DOI:

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