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题目:: Autologous mixed lymphocyte reaction in man: further characterization of responding cells.
作者:: Klajman(A),Drucker(I),Manor(Y)
状态:: 发布时间1983-06-10 , 更新时间 2013-11-21
期刊:: Immunol Lett
摘要:: Experiments were performed to determine the type of cells undergoing thymidine incorporation in 7-day autologous mixed lymphocyte reactions (AMLR). Peripheral blood mononuclear cells (PBM) were separated into B cells, T cells, B + Null cells and T + Null cell-enriched populations. Cells were cultured in various combinations. Monocytes were removed to determine their influence on AMLR. The main thymidine-incorporating cells in cultures were shown to be Null cells and to a lesser extent T cells. Monocytes were found to have a more pronounced suppressor effect on stimulation of T cells by non-T cell populations in younger individuals than in the elderly. Whether Null cells undergo a spontaneous blastogenesis in culture or are stimulated by T or B cells, could not be answered by the present investigation.
语言:: eng
DOI:

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