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PMID: 6220060 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The ontogeny of antigen-presenting cells in fetal thymus evaluated by MLR stimulation.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 130 ·No. 4 ·1983-04-00 ·Pages 1592-5

Robinson JH

Abstract

This study demonstrates that cells with the characteristics of antigen-presenting cells (APC) are present in murine thymus from as early as 14 days gestation, around the time that T lymphopoiesis is initiated in the embryo. Thymic APC were identified as la+ adherent cells capable of presenting alloantigens to T cells in MLC. The possible role of these cells in thymocyte differentiation is discussed.

MeSH Terms

Animals Cell Adhesion Cell Separation Female Histocompatibility Antigens Class II/analysis,immunology Lymphocyte Activation Lymphocyte Culture Test, Mixed Male Mice Mice, Inbred C57BL Mice, Inbred CBA Pregnancy T-Lymphocytes/immunology Thymus Gland/cytology,embryology,immunology

Chemicals

Histocompatibility Antigens Class II

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Robinson J H

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1983-04-00

Pages

1592-5

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

PubMed source View journal details

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The ontogeny of antigen-presenting cells in fetal thymus evaluated by MLR stimulation.

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