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PMID: 6217275 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Helper cell-independent cytotoxic clones in man.

The Journal of experimental medicine ·Vol. 156 ·No. 6 ·1982-12-01 ·Pages 1854-9

Wee SL, Chen LK, Strassmann G, Bach FH

Abstract

We report here a class of helper cell-independent cytotoxic T cell (HITc) clones in man that can proliferate in response to antigenic stimulation as well as mediate cytotoxicity. HITc appear to be rare among clones derived from primary in vitro allosensitized culture, but constitute the majority of clones derived from cells sensitized to autologous Epstein-Barr virus-transformed lymphoblastoid cell lines. The implications of the derivation and function of HITc clones are discussed.

MeSH Terms

Cell Line Clone Cells/immunology Cytotoxicity, Immunologic Humans Lymphocyte Activation Lymphocyte Culture Test, Mixed Melanoma/immunology T-Lymphocytes, Cytotoxic/classification,immunology T-Lymphocytes, Helper-Inducer/immunology

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Wee S L

Chen L K

Strassmann G

Bach F H

References (12)

12 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.156.6.1854

Published

1982-12-01

Pages

1854-9

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2186881

Subset

Grants

NIAID NIH HHS · AI GM 17687 · United States

External Links

PubMed source DOI: 10.1084/jem.156.6.1854 PMC Full Text View journal details

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