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PMID: 6216999 Published · ppublish English Journal Article

Regulation of the C3 nephritic factor stabilized C3/C5 convertase of complement by purified human erythrocyte C3b receptor.

Clinical and experimental immunology ·Vol. 50 ·No. 1 ·1982-10-00 ·Pages 209-14

Daha MR, Kok DJ, Van Es LA

Abstract

Activation of complement may result in the generation of the amplification convertase C3bBb. This convertase can be stabilized by properdin (P) or C3NeF. C3bBbP is susceptible to inactivation by beta 1H, while C3bBbNeF is relatively resistant. Since it has been shown that the human erythrocyte C3b receptor (CR1) is able to inactivate C3bBbP, the inactivating action of CR1 on C3bBbNeF was investigated CR1 is at least five times more efficient than beta 1H in inactivating C3bBbNeF. Kinetic studies revealed that CR1 induces an enhanced biphasic kinetics of decay of C3bBbNeF; further purification of this C3NeF preparation by cation exchange chromatography showed that this phenomenon is dependent on the population of C3NeF. Finally CR1 is also able to inactivate fluid phase C3bBbNeF.

MeSH Terms
Complement Activating Enzymes/antagonists & inhibitors,metabolism Complement C3 Nephritic Factor/immunology Complement C3-C5 Convertases/antagonists & inhibitors,metabolism Complement C3b/metabolism Complement C3b Inactivator Proteins/pharmacology Complement Factor H Complement Inactivator Proteins/immunology Erythrocytes/immunology Humans Kinetics Receptors, Complement/immunology Time Factors
Chemicals
CFH protein, human Complement C3 Nephritic Factor Complement C3b Inactivator Proteins Complement Inactivator Proteins Receptors, Complement Complement C3b Complement Factor H Complement Activating Enzymes Complement C3-C5 Convertases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Daha M R
Kok D J
Van Es L A
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18 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1982-10-00
Pages
209-14
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1536848
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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