Thrombin-induced degranulation of cultured bone marrow-derived mast cells.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 133 ·No. 6 ·1984-12-00 ·Pages 3282-5

Razin E, Marx G

Abstract

This study was undertaken to determine if a plasma protease such as thrombin, a highly specific procoagulant enzyme that has numerous effects on platelets, endothelial cells, and smooth muscle cells, could mediate mast cell activation processes. Our results indicate that at near physiologic levels, thrombin can rapidly trigger mast cell degranulation without activating the 5-lipoxygenase system.

MeSH Terms

Animals Antithrombin III/pharmacology Bone Marrow Cells Cattle Cells, Cultured Cytoplasmic Granules/metabolism Hexosaminidases/metabolism Hirudins/pharmacology Histamine Release Humans Mast Cells/metabolism Mice Substrate Specificity Thrombin/antagonists & inhibitors,pharmacology beta-N-Acetylhexosaminidases

Chemicals

Hirudins Antithrombin III Hexosaminidases beta-N-Acetylhexosaminidases Thrombin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Razin E

Marx G

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1984-12-00

Pages

3282-5

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

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Thrombin-induced degranulation of cultured bone marrow-derived mast cells.

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