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PMID: 6197122 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Substance P inhibits the M-current in bullfrog sympathetic neurones.

British journal of pharmacology ·Vol. 79 ·No. 2 ·1983-06-00 ·Pages 330-3

Adams PR, Brown DA, Jones SW

Abstract

Substance P (SP, 2.5-10 microM) was applied by rapid bath perfusion to bullfrog lumbar sympathetic neurones in vitro, voltage-clamped through a single micro-electrode. In unclamped cells, SP produced a depolarization accompanied by an increase in apparent input resistance. Under voltage-clamp a voltage-dependent inward current was induced by SP, during which the time-dependent relaxations induced by square voltage commands were inhibited. It is concluded that SP inhibits the M-current (IM), a species of voltage-dependent K+-current, and that IM-inhibition was the primary cause of the inward current and membrane depolarization in the cells tested.

MeSH Terms

Animals Ganglia, Sympathetic/drug effects,physiology In Vitro Techniques Ion Channels/drug effects Potassium/metabolism Rana catesbeiana Substance P/pharmacology

Chemicals

Ion Channels Substance P Potassium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Adams P R

Brown D A

Jones S W

References (14)

14 references, click to expand

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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1983.tb11004.x

Published

1983-06-00

Pages

330-3

Language

English

Region

England

NLM ID

7502536

PMCID

PMC2044878

Subset

Grants

NINDS NIH HHS · NS 18579 · United States

External Links

PubMed source DOI: 10.1111/j.1476-5381.1983.tb11004.x PMC Full Text View journal details

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Substance P inhibits the M-current in bullfrog sympathetic neurones.

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