Antigenic relatedness of two strains of hepatitis A virus determined by cross-neutralization.

Infection and immunity ·Vol. 42 ·No. 1 ·1983-10-00 ·Pages 418-20

Lemon SM, Binn LN

Abstract

Cell culture-adapted HM-175 (Australia) and PA-21 (Panama) strains of hepatitis A virus were compared in a cross-neutralization radioimmunofocus inhibition assay. The ratio of antibody titers achieved with two sera against the two viruses differed by less than twofold, indicating a high degree of antigenic relatedness between epidemiologically disparate strains of virus.

MeSH Terms

Antibodies, Viral/analysis Antigens, Viral/immunology Epitopes Hepatitis A Antibodies Hepatovirus/immunology Neutralization Tests Species Specificity

Chemicals

Antibodies, Viral Antigens, Viral Epitopes Hepatitis A Antibodies

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lemon S M

Binn L N

References (6)

6 references, click to expand

Etiologic relationship of marmoset-propagated CR326 hepatitis A virus to hepatitis in man.
Proc Soc Exp Biol Med. 1973 Apr;142(4):1257-67 PMID: 4632938
Similarities of two hepatitis A virus strains.
Bull World Health Organ. 1976;54(5):561-4 PMID: 194718
Propagation of human hepatitis A virus in African green monkey kidney cell culture: primary isolation and serial passage.
Infect Immun. 1981 Apr;32(1):388-93 PMID: 6260685
Transmission of hepatitis A virus among recently captured Panamanian owl monkeys.
J Med Virol. 1982;10(1):25-36 PMID: 6290600
Experimental infection of the New World owl monkey (Aotus trivirgatus) with hepatitis A virus.
Infect Immun. 1983 May;40(2):766-72 PMID: 6840861
Radioimmunofocus assay for quantitation of hepatitis A virus in cell cultures.
J Clin Microbiol. 1983 May;17(5):834-9 PMID: 6306048

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.42.1.418-420.1983

Published

1983-10-00

Pages

418-20

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC264574

Subset

External Links

PubMed source DOI: 10.1128/iai.42.1.418-420.1983 PMC Full Text View journal details

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Antigenic relatedness of two strains of hepatitis A virus determined by cross-neutralization.

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