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PMID: 6192859 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications.

Blood ·Vol. 62 ·No. 4 ·1983-10-00 ·Pages 709-21

Koeffler HP

Abstract

A prominent phenotypic abnormality of human acute myelogenous leukemia cells is the inability of the cells to differentiate to functional mature cells; instead, the cells are blocked at an early stage of development and remain in the proliferative pool and rapidly accumulate. Investigation of the induction of myeloid leukemic cell differentiation has made recent advances with the development of several human myelogenous leukemia cell lines. The lines provide models to study the biology of myeloid differentiation and to identify inducers of differentiation of myeloid leukemic blood cells. This review critically examines the inducers of leukemic cell differentiation and their potential therapeutic importance.

MeSH Terms
3-Deazauridine/pharmacology Acetamides/pharmacology Alkaloids/pharmacology Animals Calcitriol/pharmacology Cell Differentiation/drug effects Cell Line Cells, Cultured Dimethyl Sulfoxide/pharmacology Glycoproteins/pharmacology Granulocytes/cytology Growth Inhibitors Humans Hypoxanthines/pharmacology Interferons/pharmacology Interleukin-6 Leukemia Inhibitory Factor Leukemia, Myeloid, Acute/blood,pathology Lymphokines Lyngbya Toxins Macrophages/cytology Mice Phorbol Esters/pharmacology Piperidones/pharmacology Polyethylene Glycols/pharmacology Tretinoin/analogs & derivatives
Chemicals
Acetamides Alkaloids Glycoproteins Growth Inhibitors Hypoxanthines Interleukin-6 LIF protein, human Leukemia Inhibitory Factor Lif protein, mouse Lymphokines Lyngbya Toxins Phorbol Esters Piperidones 3-Deazauridine teleocidins triethylene glycol Polyethylene Glycols Tretinoin Interferons Calcitriol hexamethylene bisacetamide Dimethyl Sulfoxide
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Koeffler H P
Article Info
Journal
Blood
Abbr.
Blood
ISSN
0006-4971
Published
1983-10-00
Pages
709-21
Language
English
Region
United States
NLM ID
7603509
Subset
IM
Grants
NCI NIH HHS · CA 26038 · United States
NCI NIH HHS · CA 32737 · United States
NCI NIH HHS · CA 33936 · United States
External Links
PubMed source View journal details
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