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PMID: 6190757 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Antigenic variants are not selected during persistent infection with Theiler's virus.

Infection and immunity ·Vol. 41 ·No. 1 ·1983-07-00 ·Pages 440-2

Leibowitz JL, Rodriguez M

Abstract

In this study, we demonstrated that non-neutralizable antigenic variants of Theiler's murine encephalomyelitis virus do not predominate during the course of chronic relapsing infection.

MeSH Terms

Animals Antigens, Viral/genetics,immunology Chronic Disease Demyelinating Diseases/microbiology Enterovirus/immunology Enterovirus Infections/microbiology Epitopes Genetic Variation Maus Elberfeld virus/genetics,immunology Mice Neutralization Tests

Chemicals

Antigens, Viral Epitopes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Leibowitz J L

Rodriguez M

References (15)

15 references, click to expand

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Antigenic shift of visna virus in persistently infected sheep.
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Oligoclonal measles virus-specific IgG antibodies isolated from sera of patients with subacute sclerosing panencephalitis.
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Central nervous system immunity in mice infected with theiler's virus. I. Local neutralizing antibody response.
J Infect Dis. 1978 Feb;137(2):145-51 PMID: 203636
Oligoclonal immunoglobulins in subacute sclerosing panencephalitis and multiple sclerosis: a study of idiotypic determinants.
Clin Exp Immunol. 1979 Jan;35(1):67-75 PMID: 85508
Antigenic variation in visna virus.
Cell. 1979 Oct;18(2):321-7 PMID: 227603
Replication of Theiler's murine encephalomyelitis viruses in BHK21 cells: an electron microscopic study.
Virology. 1980 Mar;101(2):389-98 PMID: 6244696
Genomic changes associated with antigenic variation of visna virus durig persistent infection.
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4454-8 PMID: 6254026
The virus-specific intracellular RNA species of two murine coronaviruses: MHV-a59 and MHV-JHM.
Virology. 1981 Oct 15;114(1):39-51 PMID: 7281517
Ultrastructural immunohistochemical localization of virus in acute and chronic demyelinating Theiler's virus infection.
Am J Pathol. 1982 Jan;106(1):20-9 PMID: 6275708
Theiler's virus persists in glial cells during demyelinating disease.
Cell. 1981 Oct;26(1 Pt 1):123-8 PMID: 6276007
Rapid evolution of RNA genomes.
Science. 1982 Mar 26;215(4540):1577-85 PMID: 7041255
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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.41.1.440-442.1983

Published

1983-07-00

Pages

440-2

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC264801

Subset

Grants

NINDS NIH HHS · NS 07078 · United States

NINDS NIH HHS · NS 09053 · United States

NINDS NIH HHS · NS 15211 · United States

External Links

PubMed source DOI: 10.1128/iai.41.1.440-442.1983 PMC Full Text View journal details

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Antigenic variants are not selected during persistent infection with Theiler's virus.

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